Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings
| Autor: | Christina C. Lawson, Thomas H. Connor, Martha Polovich, Melissa A. McDiarmid |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Infertility Health Personnel Population MEDLINE Antineoplastic Agents Article Miscarriage Occupational Exposure Environmental health Health care medicine Humans education Reproductive health education.field_of_study business.industry Reproduction Public Health Environmental and Occupational Health medicine.disease Reproductive Health Antineoplastic Drugs Female Health Facilities business Reproductive effects |
| Zdroj: | Journal of Occupational & Environmental Medicine. 56:901-910 |
| ISSN: | 1076-2752 |
| DOI: | 10.1097/jom.0000000000000249 |
| Popis: | Objectives: Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. Methods: As tructured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Results: Although effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time to pregnancy also suggested an increased risk for subfertility.Conclusions: Antineoplastic drugs are highly toxic in patients receiving treatment, and adverse reproductive effects have been well documented in these patients. Health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered. |
| Databáze: | OpenAIRE |
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