Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury
| Autor: | Umit Yolcu, Emin Oztas, Uzeyir Erdem, Abdullah Ilhan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Ubiquinone medicine.medical_treatment Intraperitoneal injection Pharmacology Antioxidants Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Eye Injuries lcsh:Ophthalmology Burns Chemical medicine Animals Proanthocyanidins Chemical Warfare Agents Mechlorethamine Antidote Saline Coenzyme Q10 business.industry Therapeutic effect Eye injuries Histology General Medicine medicine.disease Nitrogen mustard eye diseases Rats Ophthalmology Disease Models Animal chemistry Oxidative stress lcsh:RE1-994 Mustard gas sense organs business Retinopathy |
| Zdroj: | Arquivos Brasileiros de Oftalmologia, Vol 81, Iss 3, Pp 226-231 Arquivos Brasileiros de Oftalmologia v.81 n.3 2018 Arquivos brasileiros de oftalmologia Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
| ISSN: | 1678-2925 |
| Popis: | Purpose: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. Methods: Eighteen male rats were divided into the following 4 groups: NM, NM + PAC, NM + CoQ10, and control. The 3 NM groups received a single dose of NM (0.02 mg/μL) on the right eye to induce ocular injury. The control group received saline only. Thirty minutes after the application of NM, the NM + PAC group received PAC (100 mg/kg) via gastric gavage, while the NM + CoQ10 group received CoQ10 (10 mg/kg) via intraperitoneal injection. PAC and CoQ10 were administered once a day for 5 consecutive days. The rats were then sacrificed. Macroscopic images of the eyes were examined and eye tissues were collected for histology. Results: The treatment groups were compared to the control group with regard to both corneal opacity and lid injury scores. The findings were not significantly different for both the NM + PAC and NM + CoQ10 groups. In both the NM + PAC and NM + CoQ10 groups, the histological changes seen in the NM group demonstrated improvement. Conclusions: Our results indicate that PAC and CoQ10 treatments have therapeutic effects on NM-induced ocular injury in a rat model. PAC and CoQ10 may be novel options in patients with NM-induced ocular injury. |
| Databáze: | OpenAIRE |
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