A rare but recurrent t(8;13)(q24;q14) translocation in B-cell chronic lymphocytic leukaemia causingMYCup-regulation and concomitant loss ofPVT1,miR-15/16andDLEU7

Autor: Santina Venuto, Clelia Tiziana Storlazzi, Gemma Macchia, Angelo Lonoce, Massimo Carella, P. Iuzzolino, María Hernández-Sánchez, Ettore Macrì, Jesús M. Hernández-Rivas, Orazio Palumbo, Crocifissa Lo Cunsolo
Přispěvatelé: Associazione Italiana per la Ricerca sul Cancro
Rok vydání: 2015
Předmět:
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
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ISSN: 0007-1048
DOI: 10.1111/bjh.13482
Popis: B-cell chronic lymphocytic leukaemia (B-CLL) is the most common haematological malignancy in Western countries. Trisomy 12 (12%), and deletions of 13q14 (50%), 11q23 (18%) and 17p13 (7%) are the most frequent chromosomal aberrations (Palamarchuk et al, 2010). 13q14 losses, associated with better prognosis, are primary changes resulting in loss of MIR15A/MIR16-1 and DLEU7 (Palamarchuk et al, 2010). Notably, the 10% of these deletions occur together with unbalanced translocations with multiple partners (Puiggros et al, 2014). Two cases with t(8;13)(q14;q24) translocations have been described, although not characterized at molecular level (Gardiner et al, 1997; Put et al, 2012). 8q24 rearrangements are generally rare in CLL and their prognostic significance is unclear.
This work was supported by the AIRC (Associazione Italiana per la Ricerca sul Cancro).
Databáze: OpenAIRE
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