Laryngopharyngeal Reflux and Inflammatory Responses in Mucosal Barrier Dysfunction of the Upper Aerodigestive Tract
| Autor: | Danling Liu, Tingting Qian, Shan Sun, Jack J. Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Intoxicative inhalant LPR Immunology Review 03 medical and health sciences Laryngopharyngeal reflux 0302 clinical medicine Immune system Antigen upper aerodigestive tract medicine Immunology and Allergy Risk factor business.industry laryngopharyngeal reflux Mucin mucosal barrier dysfunction inflammatory response medicine.disease 030104 developmental biology Upper aerodigestive tract 030220 oncology & carcinogenesis UAT business Intracellular |
| Zdroj: | Journal of Inflammation Research |
| ISSN: | 1178-7031 |
| Popis: | The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders. |
| Databáze: | OpenAIRE |
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