Resveratrol analogue 4,4 -dihydroxy-trans-stilbene potently inhibits cancer invasion and metastasis
| Autor: | Livia Bianchi, Barbara Mannucci, Federica Corana, Monica Savio, Daniela Ferraro, Lucia Anna Stivala, Rita Vaccarone, Yihai Cao, Cristina Maccario, Lasse Jensen |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Lung Neoplasms Cell Apoptosis Biology Resveratrol Article Metastasis Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stilbenes Human Umbilical Vein Endothelial Cells medicine Animals Humans Neoplasm Invasiveness Lung cancer Multidisciplinary Cell growth Klinisk medicin Cancer Cell migration Neoplasms Experimental Cell cycle medicine.disease Xenograft Model Antitumor Assays 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Cancer research Clinical Medicine |
| Zdroj: | Scientific Reports |
| Popis: | We investigated the preventive effects of resveratrol analogue 4,4′-dihydroxy-trans-stilbene (DHS) on cancer invasion and metastasis. Two different in vivo approaches of mouse and zebrafish lung cancer invasion models were employed in our study. The in vitro results showed that DHS displays potent inhibition on anchorage-dependent or -independent cell growth of LLC cells, leading to impairment of the cell cycle progression with reduction of cell numbers arresting at the G1 phase, an evident accumulation of pre-G1 events correlated with apoptotic behaviour. In addition, DHS induces a marked inhibition of LLC cell migration and matrigel invasion. In a murine lung cancer model, tumour volume, cell proliferation and tumour angiogenesis were significantly inhibited by DHS. Importantly, liver metastatic lesions were significantly reduced in DHS-treated mice. Similarly, DHS significantly inhibits lung cancer cell dissemination, invasion and metastasis in a zebrafish tumour model. These findings demonstrate that DHS could potentially be developed as a novel therapeutic agent for treatment of cancer and metastasis. |
| Databáze: | OpenAIRE |
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