Histopathologic features of Buruli ulcer patients in a referral hospital in South Eastern Nigeria

Autor: Chijioke A. Ezenyeaku, Chinomnso C. Nnebue, Ifeoma A. Njelita, Chinyerem C. Nwachukwu, Darlington C. Obi, Chioma C. Ajator, Ahoma V. Mbanuzuru, Cyril C. Ezenyeaku, Anthony A. Agbata
Jazyk: angličtina
Rok vydání: 2023
Předmět:
ISSN: 2394-7330
DOI: 10.5281/zenodo.8074811
Popis: Background: Buruli ulcers are characterized by massive subcutaneous tissue destruction which can be treated effectively and completely when detected early. Characteristic histopathologic changes are considered one of the confirmatory laboratory methods for the diagnosis of Buruli ulcers. Objective: To assess the histopathologic features of Buruli ulcer cases presenting in a referral hospital in South Eastern Nigeria. Methods: A cross-sectional prospective study was carried out among a cohort of 39 Buruli ulcer disease patients referred to a referral hospital in South Eastern Nigeria between July and December 2021. A semi-structured, interviewer-administered questionnaire was used to collect data on the socio-demographic characteristics of the respondents while the incisional skin biopsy specimens obtained from the patients in the course of their treatments were sent for histopathologic evaluation. Data were analyzed using SPSS version 22; with alpha set at p-value ≤ 0.05. Results: Twenty one (53.8%) of the study participants were males while 18 (46.2%) were females. Their mean age was 28.41±18.668. Epidermal hyperplasia and elastolysis of the dermis were present in 35 (89.7%) of the patients. There was inflammation of the dermis and subcutis in 34 (87.2%) of the patients while necrosis of the subcutis was present in 38 (97.4%) of the patients. AFB was not visualized in any of the lesions of the patients. Overall, the characteristic histopathologic features of Buruli ulcer were demonstrated in 33 (84.6%) of the patients and four (10.3%) of the patients had features of squamous cell carcinoma while 2 (5.1%) had features of varicose veins. Keywords: Buruli ulcer, histopathology, hospital, Nigeria , Patient, South East. Title: Histopathologic features of Buruli ulcer patients in a referral hospital in South Eastern Nigeria Author: Chijioke A. Ezenyeaku, Chinomnso C. Nnebue, Ifeoma A. Njelita, Chinyerem C. Nwachukwu, Darlington C. Obi, Chioma C. Ajator, Ahoma V. Mbanuzuru, Cyril C. Ezenyeaku, Anthony A. Agbata International Journal of Novel Research in Healthcare and Nursing ISSN 2394-7330 Vol. 10, Issue 2, May 2023 - August 2023 Page No: 133-144 Novelty Journals Website: www.noveltyjournals.com Published Date: 23-June-2023 DOI: https://doi.org/10.5281/zenodo.8074812 Paper Download Link (Source) https://www.noveltyjournals.com/upload/paper/Histopathologic%20features%20of%20Buruli-23062023-4.pdf
International Journal of Novel Research in Healthcare and Nursing, ISSN 2394-7330, Novelty Journals, Website: www.noveltyjournals.com
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