Confounding factors in the assessment of oral mucositis in head and neck cancer
| Autor: | Luigi Lorini, Francesco Perri, Stefania Vecchio, Liliana Belgioia, Marie Vinches, Irene Brana, Sharon Elad, Paolo Bossi |
|---|---|
| Přispěvatelé: | Institut Català de la Salut, Radiological Sciences & Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy. [Perri F] Head and Neck Cancer Unit, Istituto Nazionale Tumori Di Napoli, IRCCS 'G. Pascale', Naples, Italy. [Vecchio S] Medical Oncology, IRCCS San Martino, IST National Cancer Institute and University of Genova, Genoa, Italy. [Belgioia L] Radiation Oncology Department, Health Science Department (DISSAL), IRCCS Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy. [Vinches M] Montpellier Cancer Research Institute, Montpellier, Languedoc-Roussillon, France. [Brana I] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Elad S] Oral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Mucositis
Stomatitis Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Mucositis [DISEASES] Simultaneous care Mucosa oral - Malalties Therapeutics::Radiotherapy [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Coll - Càncer - Radioteràpia Otros calificadores::Otros calificadores::/efectos adversos [Otros calificadores] Cap - Càncer - Radioteràpia Head and neck Oncology terapéutica::radioterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Head and Neck Neoplasms Radiation toxicities Supportive care Neoplasms::Neoplasms by Site::Head and Neck Neoplasms [DISEASES] enfermedades del sistema digestivo::enfermedades gastrointestinales::gastroenteritis::mucositis [ENFERMEDADES] Quality of Life Other subheadings::Other subheadings::/adverse effects [Other subheadings] Humans neoplasias::neoplasias por localización::neoplasias de cabeza y cuello [ENFERMEDADES] |
| Zdroj: | Scientia |
| Popis: | Mucositis; Radiation toxicities; Simultaneous care Mucositis; Toxicitats per radiació; Atenció simultània Mucositis; Toxicidades por radiación; Atención simultánea Treatment of locally advanced head and neck carcinoma not amenable for surgical resection or resected with high-risk features is usually based on (chemo-)radiation treatment. Oral mucositis represents one of the main side effects of (chemo-)radiation, with an important impact on quality of life and causing approximately 20% of early interruption of treatment, leading to a suboptimal dose administered. Treatment and prevention of oral mucositis have a central role in the therapeutic pathways of head and neck cancer patients but remains quite challenging. Although extensive research is conducted to identify interventions for the management of mucositis, very few interventions had sufficient evidence to generate an international expert consensus. This may be partially explained by confounding factors that could influence the development and assessment of oral mucositis. Little is known about the confounding factors of oral mucositis, which, if not well balanced in an experimental study, could lead to non-solid results. The current paper aims to review the main oral mucositis confounding factors related to head and neck cancer patients. Open access funding provided by Università degli Studi di Brescia within the CRUI-CARE Agreement. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. |
| Databáze: | OpenAIRE |
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