Juvenile rhesus monkeys have more colonic granulomas than adults after primary infection with Schistosoma mansoni
| Autor: | Padraic G. Fallon, Eric Van Marck, André M. Deelder, Johannes Bogers, Alan W. Thomas, Jan A.M. Langermans, Shyama Chatterjee, Werner Jacobs, David W. Dunne |
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| Rok vydání: | 2004 |
| Předmět: |
Helminthiasis
Schistosomiasis Ileum Pathology and Forensic Medicine Colonic Diseases medicine Animals Parasite hosting Juvenile Molecular Biology Granuloma biology Liver Diseases Age Factors Schistosoma mansoni Cell Biology General Medicine biology.organism_classification medicine.disease Immunohistochemistry Macaca mulatta Schistosomiasis mansoni medicine.anatomical_structure Immunology Female Disease Susceptibility Trematoda |
| Zdroj: | Virchows Archiv |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-004-1083-4 |
| Popis: | Adults and children have differences in their susceptibility to schistosomiasis. Whether this age-dependent innate susceptibility influences parasite-caused granulomogenesis is difficult to assess in humans. Therefore, we exposed juvenile and adult female rhesus monkeys to primary infection with Schistosoma mansoni. Hepatic and intestinal granuloma formation was observed in both pre-pubescent and adult monkeys. Two distinct stages of granulomas were discerned, the exudative and the productive stage. In the intestine, more granulomas were generated in the colon than in the ileum. In contrast to the adult animals, the juvenile rhesus monkeys had higher numbers of colonic granulomas, these higher numbers being predominantly of the more advanced productive stage. Juvenile animals had a statistically non-significant increased worm burden. These results suggest that juvenile rhesus monkeys have a significantly more intense and advanced colonic response towards entrapped S. mansoni eggs after primary schistosome infections and, thereby, are more susceptible to parasite infection. |
| Databáze: | OpenAIRE |
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