An Organoselenium Compound Inhibits Staphylococcus aureus Biofilms on Hemodialysis Catheters In Vivo
| Autor: | Jane A. Colmer-Hamood, Eric Tobin, Thomas Mosley, Abdul N. Hamood, Nathan Lowry, Phat Tran, Ted W. Reid, Janet Dertien, Thomas Campbell, Arash Aslani, Daniel R. Webster |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Catheterization
Central Venous Staphylococcus aureus Hemodialysis Catheter medicine.disease_cause Microbiology Catheters Indwelling In vivo Renal Dialysis Organoselenium Compounds medicine Pharmacology (medical) Experimental Therapeutics Pharmacology biology Chemistry Biofilm Pathogenic bacteria Antimicrobial biology.organism_classification In vitro Anti-Bacterial Agents Infectious Diseases Biofilms Catheter-Related Infections Equipment Contamination Bacteria |
| Popis: | Colonization of central venous catheters (CVCs) by pathogenic bacteria leads to catheter-related bloodstream infections (CRBSIs). These colonizing bacteria form highly antibiotic-resistant biofilms. Staphylococcus aureus is one of the most frequently isolated pathogens in CRBSIs. Impregnating CVC surfaces with antimicrobial agents has various degrees of effectiveness in reducing the incidence of CRBSIs. We recently showed that organoselenium covalently attached to disks as an antibiofilm agent inhibited the development of S. aureus biofilms. In this study, we investigated the ability of an organoselenium coating on hemodialysis catheters (HDCs) to inhibit S. aureus biofilms in vitro and in vivo . S. aureus failed to develop biofilms on HDCs coated with selenocyanatodiacetic acid (SCAA) in either static or flowthrough continuous-culture systems. The SCAA coating also inhibited the development of S. aureus biofilms on HDCs in vivo for 3 days. The SCAA coating was stable and nontoxic to cell culture or animals. This new method for coating the internal and external surfaces of HDCs with SCAA has the potential to prevent catheter-related infections due to S. aureus . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|