BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection
| Autor: | Marc Barry, Youngho Kim, Yijuan Sun, Darlene Vigil, Antonios H. Tzamaloukas, Nikifor K. Konstantinov, Karen S. Servilla, Antonia Harford, Kavitha Ganta |
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| Rok vydání: | 2016 |
| Předmět: |
Cardiac transplant
medicine.medical_treatment 030232 urology & nephrology Review 030230 surgery medicine.disease_cause Nephrotoxicity Nephropathy 03 medical and health sciences 0302 clinical medicine medicine Liver transplant Transplantation medicine.diagnostic_test business.industry Ureteritis Immunosuppression medicine.disease Pancreatic transplant BK virus BK nephropathy Bone marrow transplant Immunology Renal biopsy BK viral infection business Viral load Lung transplant Kidney disease |
| Zdroj: | World Journal of Transplantation |
| ISSN: | 2220-3230 |
| DOI: | 10.5500/wjt.v6.i3.472 |
| Popis: | Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. |
| Databáze: | OpenAIRE |
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