Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study
| Autor: | Sándor Fekete, Ádám Feldmann, María Rosa Simón, Eszter Varga, Tamás Tényi, F. Nagy, Róbert Herold, Ferenc Kövér |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Adolescent Neuropsychological Tests Grey matter Audiology computer.software_genre Hippocampus behavioral disciplines and activities Temporal lobe Young Adult Reference Values Voxel Cerebellum Theory of mind mental disorders Image Processing Computer-Assisted medicine Humans Dominance Cerebral Personal Construct Theory Cerebral Cortex Psychiatric Status Rating Scales Organ Size Voxel-based morphometry medicine.disease Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health medicine.anatomical_structure Frontal lobe Schizophrenia Female Schizophrenic Psychology Orbitofrontal cortex Psychology Neuroscience computer |
| Zdroj: | Acta Psychiatrica Scandinavica. 119:199-208 |
| ISSN: | 1600-0447 0001-690X |
| DOI: | 10.1111/j.1600-0447.2008.01297.x |
| Popis: | Objective: We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia. Method: Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks. Results: Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole. Conclusion: Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia. |
| Databáze: | OpenAIRE |
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