In vivo pharmacodynamic and pharmacokinetic interactions ofHibiscus sabdariffacalyces extracts with simvastatin
| Autor: | Sharon I. Igbinoba, Titilayo O. Fakeye, Segun J Showande, Olayemi M. Adegbolagun |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Simvastatin Herb-Drug Interactions Bioequivalence Pharmacology 030226 pharmacology & pharmacy 01 natural sciences Young Adult 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Animals Humans Medicine Pharmacology (medical) Rats Wistar Hypolipidemic Agents Cross-Over Studies medicine.diagnostic_test biology Plant Extracts business.industry Hibiscus sabdariffa nutritional and metabolic diseases Hibiscus biology.organism_classification Crossover study Rats 0104 chemical sciences Disease Models Animal 010404 medicinal & biomolecular chemistry Pharmacodynamics Female lipids (amino acids peptides and proteins) business Lipid profile medicine.drug |
| Zdroj: | Journal of Clinical Pharmacy and Therapeutics. 42:695-703 |
| ISSN: | 0269-4727 |
| Popis: | SummaryWhat is known and objectives Increasing number of patients use herbs with their medications. Such practice may result in beneficial or harmful herb-drug interactions. A recent survey reported that some participants co-administered Hibiscus sabdariffa, a widely used beverage, or tea, with their antihyperlipidaemic medications. This study therefore evaluated the effect of concomitant administration of Hibiscus sabdariffa calyces' extracts with simvastatin on hyperlipidaemia and pharmacokinetics of the drug in vivo. Methods Factorial experimental designs were used to evaluate the comparative effectiveness and interactions between simvastatin and aqueous extract of Hibiscus sabdariffa (AEHS) on lipid profile parameters in hyperlipidaemia-induced Wistar rats. Different combinations of low (AEHS 250 mg/kg; simvastatin 10 mg/kg) and high doses (AEHS 500 mg/kg; simvastatin 20 mg/kg) were administered individually and concurrently daily for 2 and 4 weeks. Lipid profile parameters were assessed at these treatment periods. Subsequently, the effect of aqueous beverage of Hibiscus sabdariffa (ABHS) on the pharmacokinetics of single-dose 40 mg simvastatin was also evaluated in six healthy human volunteers using two-period randomized crossover design. Blood samples were collected at predetermined times for 24 hours. The plasma obtained was analysed for simvastatin using RP-HPLC/UV method. Results Aqueous extract of Hibiscus sabdariffa reduced total cholesterol (Tc) better than simvastatin (P = .031). Low-dose AEHS and low-dose simvastatin used concomitantly caused 38.3% and 57.4% reductions in Tc and triglyceride levels, respectively, compared with low-dose simvastatin (P |
| Databáze: | OpenAIRE |
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