Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge
| Autor: | Stephanie K. Yanow, Kurt A Wong, Moses Lee, Lisa A. Purcell, Ana Rodriguez, Terry W. Spithill |
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| Rok vydání: | 2008 |
| Předmět: |
Protozoan Vaccines
Indoles Plasmodium berghei Antibodies Protozoan Heterologous Antigens Protozoan Cross immunity CD8-Positive T-Lymphocytes Cross Reactions Vaccines Attenuated Plasmodium Article Microbiology Interferon-gamma Mice Immune system Immunity parasitic diseases Animals Mice Inbred BALB C General Veterinary General Immunology and Microbiology biology Vaccination fungi Public Health Environmental and Occupational Health Plasmodium yoelii biology.organism_classification Virology Malaria Infectious Diseases Gene Expression Regulation Sporozoites Molecular Medicine Female |
| Zdroj: | Vaccine. 26:4880-4884 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2008.07.017 |
| Popis: | Vaccination with Plasmodium sporozoites attenuated by irradiation or genetic manipulation induces a protective immune response in rodent malaria models. Recently, vaccination with chemically attenuated P. berghei sporozoites (CAS) has also been shown to elicit sterile immunity in mice. Here we show that vaccination with CAS of P. yoelii also protects against homologous infection and that a P. berghei CAS vaccine cross protects against heterologous challenge with P. yoelii sporozoites. Vaccination with P. yoelii or P. berghei CAS induced parasite-specific antibodies and IFN-gamma-producing CD8(+) T cells at levels not significantly different from radiation-attenuated sporozoites. Our findings provide an initial characterization of the immune response generated by CAS vaccination and suggest that this attenuation process could be used in the production of an effective cross-protective liver stage vaccine for malaria. |
| Databáze: | OpenAIRE |
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