Elevated Plasma Surfactant Protein D (SP‐D) Levels and a Direct Correlation with Anti‐severe Acute Respiratory Syndrome Coronavirus‐specific IgG Antibody in SARS Patients
| Autor: | N Y Mao, Zuo Li Xia, Kenneth B.M. Reid, P. G. De Groot, W B Xu, Uffe Holmskov, Shao Dong Pan, Zhihua Liu, Ya Ping Wu, Grith Lykke Sørensen, Ran Wei, F S Zhang, Ji Ju Han, Biao Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Adolescent Phagocytosis Immunology Enzyme-Linked Immunosorbent Assay medicine.disease_cause Antibodies Viral Severe Acute Respiratory Syndrome Immune system medicine Coronavirus Nucleocapsid Proteins Humans skin and connective tissue diseases Child Aged biology Streptococcus Reverse Transcriptase Polymerase Chain Reaction fungi Surfactant protein D Lectin General Medicine Middle Aged Nucleocapsid Proteins SARS Virus medicine.disease Pulmonary Surfactant-Associated Protein D Recombinant Proteins body regions Pneumonia Severe acute respiratory syndrome-related coronavirus Child Preschool Immunoglobulin G biology.protein Biomarker (medicine) Biological Markers Clinical Immunology Female Antibody Biomarkers |
| Zdroj: | Scandinavian Journal of Immunology Wu, Y P, Liu, Z H, Wei, R, Pan, S D, Mao, N Y, Chen, B, Han, J J, Zhang, F S, Holmskov, U, Xia, Z L, de Groot, P G, Reid, K B M, Xu, W B & Sørensen, G L 2009, ' Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients ', Scandinavian Journal of Immunology, vol. 69, no. 6, pp. 508-15 . https://doi.org/10.1111/j.1365-3083.2009.02245.x |
| ISSN: | 1365-3083 0300-9475 |
| DOI: | 10.1111/j.1365-3083.2009.02245.x |
| Popis: | Pulmonary SP‐D is a defence lectin promoting clearance of viral infections. SP‐D is recognized to bind the S protein of SARS‐CoV and enhance phagocytosis. Moreover, systemic SP‐D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP‐D, SARS‐type pneumonia and the SARS‐specific IgG response. Sixteen patients with SARS, 19 patients with community‐acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP‐D and anti‐SARS‐CoV N protein IgG were measured using ELISA. SP‐D was significantly elevated in SARS‐type pneumonia [median (95% CI), 453 (379–963) ng/ml versus controls 218 (160–362) ng/ml, P |
| Databáze: | OpenAIRE |
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