Autonomic dysfunction in perennial vasomotor rhinitis and the effect of mequitazine
| Autor: | Pitois M, Mayeux D, Rivasseau J, Grilliat Jp, C. Kohler, Le Van D |
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| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Tachycardia Bradycardia Adolescent Baroreflex Autonomic Nervous System Placebos Phenylephrine Double-Blind Method Heart Rate Phenothiazines Vasomotor Rhinitis Isoprenaline medicine Humans Pulse Mequitazine Vasomotor business.industry Isoproterenol General Medicine Middle Aged Nasal Mucosa Rhinitis Vasomotor Anesthesia Female medicine.symptom business medicine.drug |
| Zdroj: | Current Medical Research and Opinion. 10:330-338 |
| ISSN: | 1473-4877 0300-7995 |
| DOI: | 10.1185/03007998609111099 |
| Popis: | SummaryThirty patients with perennial vasomotor rhinitis were submitted to pharmacological tests to assess the autonomic responsiveness of extra-nasal and intra-nasal receptors to isoprenaline and phenylephrine by infusion, and to evaluate the effect of 14-days' treatment with mequitazine (5 mg twice daily) and placebo on clinical symptoms and on autonomic sensitivity. Isoprenaline induced a similar tachycardia in all patients, more pronounced than that observed in normal subjects, at the different times of testing, and also an increase in nasal resistance. With phenylephrine, marked bradycardia was observed, reflecting high vagal baroreflex sensitivity, and a transient decrease in nasal resistance was obtained. Mequitazine improved significantly the clinical symptoms but did not modify the autonomic receptivity. It is suggested that in patients with vasomotor rhinitis an autonomic dysfunction may play a role in a predisposing factor in nasal hyper-reactivity with non-specific histamine release. |
| Databáze: | OpenAIRE |
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