Sexually dimorphic subcortical brain volumes in emerging psychosis
| Autor: | Andor E. Simon, Christian G. Huber, Anita Riecher-Rössler, Erich Studerus, Renata Smieskova, Claudia Lenz, Fabienne Harrisberger, Laura Egloff, André Schmidt, Stefan Borgwardt, Undine E. Lang |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis Hippocampus Physiology 03 medical and health sciences 0302 clinical medicine medicine Humans Biological Psychiatry Sex Characteristics medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Organ Size medicine.disease Magnetic Resonance Imaging 030227 psychiatry Sexual dimorphism Psychiatry and Mental health Psychotic Disorders Schizophrenia Mental state Mixed effects Female business 030217 neurology & neurosurgery Sex characteristics |
| Zdroj: | Schizophrenia Research. 199:257-265 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2018.03.034 |
| Popis: | In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for psychosis and in first episode psychosis (FEP) patients.; Data from 65 ARMS (48 (73.8%) male; age=25.1±6.32) and 50 FEP (37 (74%) male; age=27±6.56) patients were compared to those of 70 healthy controls (HC; 27 (38.6%) male; age=26±4.97). Structural T1-weighted images were acquired using a 3 Tesla magnetic resonance imaging (MRI) scanner. Linear mixed effects models were used to investigate whether subcortical brain volumes are dependent on sex.; We found men to have larger total brain volumes (p |
| Databáze: | OpenAIRE |
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