Aqueous Stable Gold Nanostar/ZIF‐8 Nanocomposites for Light‐Triggered Release of Active Cargo Inside Living Cells
| Autor: | Raquel Martínez, Mahmoud Soliman, Ana Arenas-Vivo, Alessandro Olgiati, Patricia Horcajada, María F. Navarro Poupard, Ramon A. Alvarez-Puebla, Sara Fernández-Castillejo, Carolina Carrillo-Carrión, Wolfgang J. Parak, Pablo del Pino, Beatriz Pelaz, Rosa Solà, Ester Polo, Úrsula Catalán, Pablo Taboada |
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| Přispěvatelé: | Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares, Universidade de Santiago de Compostela. Departamento de Física de Partículas |
| Jazyk: | angličtina |
| Předmět: |
Bisbenzimide
Materials science 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis law.invention Nanocomposites chemistry.chemical_compound symbols.namesake Confocal microscopy law Molecule Plasmon Aqueous solution Nanocomposite 010405 organic chemistry General Chemistry Drug release General Medicine Metal-organic frameworks Thermoplasmonics 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry symbols Biophysics Absorption (chemistry) Raman spectroscopy 0210 nano-technology ZIF-8 |
| Zdroj: | Angewandte Chemie International Edition Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela instname |
| ISSN: | 1521-3773 1433-7851 |
| DOI: | 10.1002/anie.201902817 |
| Popis: | This is the peer reviewed version of the following article: C. Carrillo-Carrión, R. Martínez, M. F. Navarro Poupard, B. Pelaz, E. Polo, A. Arenas-Vivo, A. Olgiati, P. Taboada, M. G. Soliman, Ú. Catalán, S. Fernández-Castillejo, R. Solà, W. J. Parak, P. Horcajada, R. A. Alvarez-Puebla, P. del Pino, Angew. Chem. Int. Ed. 2019, 58, 7078, which has been published in final form at https:// doi.org/10.1002/anie.201902817. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions A plasmonic core–shell gold nanostar/zeolitic‐imidazolate‐framework‐8 (ZIF‐8) nanocomposite was developed for the thermoplasmonic‐driven release of encapsulated active molecules inside living cells. The nanocomposites were loaded, as a proof of concept, with bisbenzimide molecules as functional cargo and wrapped with an amphiphilic polymer that prevents ZIF‐8 degradation and bisbenzimide leaking in aqueous media or inside living cells. The demonstrated molecule‐release mechanism relies on the use of near‐IR light coupled to the plasmonic absorption of the core gold nanostars, which creates local temperature gradients and thus, bisbenzimide thermodiffusion. Confocal microscopy and surface‐enhanced Raman spectroscopy (SERS) were used to demonstrate bisbenzimide loading/leaking and near‐IR‐triggered cargo release inside cells, thereby leading to DNA staining This work has received financial support from the MINECO‐Spain (MAT2016‐80266‐R, MAT2015‐74381‐JIN, CTQ2017‐88648R, ENE2016‐79608‐C2‐1‐R, CTQ2017‐89588‐R, RYC‐2014‐15039, RYC‐2014‐16962), the Xunta de Galicia, Centro singular de investigación de Galicia accreditation 2016–2019 (ED431G/09), the Agrupación Estratégica de Materiales Action (ED431E 2018/08), the Generalitat de Cataluña (2017SGR522, 2017SGR883, SLT002/16/00239), the URV (2017PFR‐URV‐B2‐02), the German Research Society (DFG PA 794‐21‐1), and the European Union (European Regional Development Fund—ERDF, H2020‐MSCA‐IF‐2016, project 749667). M.F.N.P acknowledges the CONACYT PhD fellowship program SI |
| Databáze: | OpenAIRE |
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