TAOK1 positively regulates TLR4-induced inflammatory responses by promoting ERK1/2 activation in macrophages
| Autor: | Rui Yang, Lingxi Zhu, Jing Xu, Peng Gao, Qingzhuo Yu, Hongbin Yuan, Ruihua Ji, Xianwei Ma, Huazhang An, Xiaogang Luo, Guixian Jiang, Jun Zhou, Qianru Liu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Kinase Chemistry medicine.medical_treatment Immunology Regulator Inflammation Cell biology Amino acid kinase 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cytokine Deficient mouse medicine TLR4 medicine.symptom Molecular Biology Function (biology) 030215 immunology |
| Zdroj: | Molecular immunology. 122 |
| ISSN: | 1872-9142 |
| Popis: | Thousand and one amino acid kinase 1 (TAOK1) is a member of Ste20-like kinases, but its function in regulating inflammatory responses remains largely unknown. In this study, we identify TAOK1 as a positive regulator of TLR4-triggered inflammatory responses in macrophages. TAOK1 increases LPS-induced production of pro-inflammatory cytokine such as IL-6, TNF-α and IL12p40 in macrophages. TAOK1 deficient mice showed decreased susceptibility to endotoxin shock, with less pro-inflammatory cytokine production than control mice. TAOK1 promotes LPS-induced activation of ERK1/2 by constitutively interacting with TRAF6 and TPL2. These finding unravel the important role of TAOK1 as a positive regulator of TLR4-induced inflammatory responses. |
| Databáze: | OpenAIRE |
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