Vegetable oil-based hybrid microparticles as a green and biocompatible system for subcutaneous drug delivery
| Autor: | Nelly Pirot, Jean-Marie Devoisselle, Aurélien Lebrun, Nadir Bettache, Aurélie Escande, Ilaria Basile, Koceïla Doufène, Joël Chopineau, Anne Aubert-Pouëssel |
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| Přispěvatelé: | Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hydrosciences Montpellier (HSM), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), NanoMedSyn (NMS), Institut du Cancer de Montpellier (ICM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2021 |
| Předmět: |
Biocompatible
Drug Octanol Castor Oil media_common.quotation_subject Subcutaneous drug delivery Pharmaceutical Science 02 engineering and technology Sol–gel 030226 pharmacology & pharmacy HeLa Mice 03 medical and health sciences Subcutaneous injection chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine medicine Animals Plant Oils [CHIM]Chemical Sciences Particle Size media_common Chromatography Estradiol biology Chemistry 021001 nanoscience & nanotechnology Biocompatible material biology.organism_classification Vegetable oil Pharmaceutical Preparations Castor oil Green process Drug delivery Solvents 0210 nano-technology medicine.drug |
| Zdroj: | International Journal of Pharmaceutics International Journal of Pharmaceutics, Elsevier, 2021, 592, pp.120070. ⟨10.1016/j.ijpharm.2020.120070⟩ International Journal of Pharmaceutics, 2021, 592, pp.120070. ⟨10.1016/j.ijpharm.2020.120070⟩ |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2020.120070 |
| Popis: | International audience; The aim of this study was to evidence the ability of vegetable oil-based hybrid microparticles (HMP) to be an efficient and safe drug delivery system after subcutaneous administration. The HMP resulted from combination of a thermostabilized emulsification process and a sol-gel chemistry. First of all, castor oil was successfully silylated by means of (3-Isocyanatopropyl)trimethoxysilane in solvent-free and catalyst-free conditions. Estradiol, as a model drug, was dissolved in silylated castor oil (ICOm) prior to emulsification, and then an optimal sol-gel crosslinking was achieved inside the ICOm microdroplets. The resulting estradiol-loaded microparticles were around 80 µm in size and allowed to entrap 4 wt% estradiol. Their release kinetics in a PBS/octanol biphasic system exhibited a one-week release profile, and the released estradiol was fully active on HeLa ERE-luciferase ERα cells. The hybrid microparticles were cytocompatible during preliminary tests on NIH 3T3 fibroblasts (ISO 10993-5 standard) and they were fully biocompatible after subcutaneous injection on mice (ISO 10993-6 standard) underlining their high potential as a safe and long-acting subcutaneous drug delivery system. |
| Databáze: | OpenAIRE |
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