Cross-sectional multicenter observational study of psoriatic arthritis in Japanese patients: Relationship between skin and joint symptoms and results of treatment with tumor necrosis factor-α inhibitors

Autor:	Motonobu Nakamura, Sakae Kaneko, Hiroko Fukamatsu, Kentaro Yonekura, Ryosuke Hino, Michiya Yamaguchi, Kenichi Morimoto, Bungo Ohyama, Takeshi Nakahara, Chika Ohata, Satoko Kikuchi, Toshihiro Sato, Shinichi Imafuku, Tetsuji Yanase, Shin Morizane, Kazunari Sugita, Kanami Saito, Kotaro Ito, Hideki Koketsu, Noriko Tsuruta, Masutaka Furue, Yutaka Narisawa, Hiroaki Hayashi, Kazuki Yamaguchi, Maki Kuwashiro, Fusako Okazaki, Chikage Mitoma, Shigeto Yanagihara, Kenzo Takahashi, Takuya Miyagi
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Inflammatory arthritis Dermatology Severity of Illness Index Dactylitis 030207 dermatology & venereal diseases 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Japan Psoriasis Internal medicine medicine Humans Immunologic Factors Age of Onset Lost to follow-up Retrospective Studies Skin Biological Products Tumor Necrosis Factor-alpha business.industry Arthritis Psoriatic Age Factors Enthesitis Retrospective cohort study General Medicine Middle Aged medicine.disease Cross-Sectional Studies Treatment Outcome 030220 oncology & carcinogenesis Quality of Life Female medicine.symptom Age of onset business
Zdroj:	The Journal of Dermatology. 46:193-198
ISSN:	0385-2407
DOI:	10.1111/1346-8138.14745
Popis:	Psoriatic arthritis (PsA) is an inflammatory arthritis with as yet unclear pathophysiology. This retrospective, multicenter, cross-sectional study was conducted in 19 facilities in western Japan and aimed to identify patients' characteristics and factors that affect the results of treatment with biologic agents. Of 2116 patients with psoriasis, 285 (13.5%) had PsA. Skin manifestations preceded joint manifestations in 69.8%, the onset was simultaneous in 17.2%, whereas PsA preceded skin manifestations in 2.5%. Peripheral arthritis was most common, occurring in 73.7%, compared with axial disease in 21.8%, enthesitis in 23.5% and dactylitis in 35.4%. Patients with severe skin manifestations were significantly younger at onset (P = 0.02) and more frequently had axial disease (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595974a0f46f8bf261c30bf148374cb7 https://doi.org/10.1111/1346-8138.14745 Zobrazit plný text záznamu Plný text