Host–Guest Inclusion Complexes of Essential Oils with Strong Antibacterial and Antifungal Features in Beta-Cyclodextrin for Solid-State Pharmaceutical Applications
| Autor: | Alice Caramaschi, Aldo Arrais, Valentina Gianotti, Nadia Massa, Alessia Cattaneo, Elisa Gamalero, Giorgia Novello, Marta Manzoni, Elisa Bona |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Antifungal Technology QH301-705.5 medicine.drug_class QC1-999 030106 microbiology Solid-state law.invention beta-cyclodextrin 03 medical and health sciences Candida sp law medicine Organic chemistry General Materials Science Biology (General) essential oils QD1-999 Instrumentation Essential oil Fluid Flow and Transfer Processes chemistry.chemical_classification host–guest molecular inclusion complexes antibacterial and antifungal performance Cyclodextrin biology Physics Process Chemistry and Technology General Engineering S. aureus Engineering (General). Civil engineering (General) biology.organism_classification Computer Science Applications Chemistry 030104 developmental biology chemistry solid-state tablet Drug release Winter savory Pharmaceutics TA1-2040 |
| Zdroj: | Applied Sciences, Vol 11, Iss 6597, p 6597 (2021) Applied Sciences Volume 11 Issue 14 |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app11146597 |
| Popis: | Essential oils are widely recognized as natural alternatives to pharmaceutical antibacterial and antifungal agents. With respect to standard pharmaceutics, the advantages of essential oils are their (i) low production costs, (ii) lack of chemical and biochemical drawbacks that are intrinsic to the synthetic production process and (iii) good tolerance by humans. On the other hand, the liquid nature of essential oils poses concerns about their actual application in different therapeutic issues regarding their persistence and the ability to control or prolong drug release. In this study, two essential oils from oregano and winter savory showing antibacterial and antifungal features were complexed in a solid state with beta-cyclodextrin. Host–guest inclusion complexes were characterized using FT-IR spectroscopy, ESI-MS and GC-MS techniques. Manyfold terpenic and non-terpenic components of the oils could be observed and unambiguously identified as being included inside the carbohydrate hosts. Many of them provided a specific biocidal action. Indeed, essential oil host–guest inclusion products were tested against two Candida species and an S. aureus reference strain, showing that the oils effectively maintained their liquid performances. Solid-state tablets of the essential oil inclusion complexes embedded in polyvinylpyrrolidone could be obtained. These results pave the way for the solid-state application of essential oils in antibacterial and antifungal pharmaceutical treatments. |
| Databáze: | OpenAIRE |
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