Taxanes from Shells and Leaves of Corylus avellana
Autor: | Andrea Armirotti, Laura Ottaggio, Alessandro Balbi, Gianluca Damonte, Federica Bestoso, Monica Sancandi, Mariangela Miele, Mauro Mazzei |
---|---|
Rok vydání: | 2008 |
Předmět: |
Paclitaxel
Pharmaceutical Science Pharmacognosy Analytical Chemistry chemistry.chemical_compound Drug Discovery Botany Humans Pharmacology Plants Medicinal biology Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Taxus brevifolia Plant Leaves Complementary and alternative medicine Taxus chemistry Italy Baccatin III visual_art visual_art.visual_art_medium Molecular Medicine Bark Taxoids Diterpene Drug Screening Assays Antitumor |
Zdroj: | Journal of natural products. 71(1) |
ISSN: | 0163-3864 |
Popis: | Paclitaxel is an effective antineoplastic agent originally extracted in low yield from the bark of Taxus brevifolia. Although it was generally considered a particular metabolite of Taxus sp., paclitaxel was recently found in hazel cell cultures. The aim of the present work was to verify whether hazel differentiated tissues could be used as a commercial source of paclitaxel and other taxanes. Thus, shells and leaves of hazel plants were analyzed by ELISA and HPLC-MS. Both shell and leaf extracts contained taxanes. Among these, paclitaxel, 10-deacetylbaccatin III, baccatin III, paclitaxel C, and 7-epipaclitaxel were identified and quantified. Hazel extracts also showed biological activity, inhibiting metaphase to anaphase transition in a human tumor cell line. The level of total taxanes in leaves was higher than in shells collected in the same period from the same plants. However, the finding of these compounds in shells, which are considered discarded material and are mass produced by many food industries, is of interest for the future availability of paclitaxel and other antineoplastic compounds. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.