SOCS3 Gene Polymorphism and Hypertension Susceptibility in Chinese Population: A Two-Center Case-Control Study
| Autor: | Lingyun Liu, Yuanlin Xie, Meiling Zuo, Dabin Kuang, Zhousheng Yang, Li-Chen Dong, Tao-Ming Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male China Article Subject Adolescent Genotype Inflammation Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Young Adult Asian People Gene Frequency Polymorphism (computer science) Risk Factors Medicine Humans Genetic Predisposition to Disease SOCS3 RNA Messenger Allele Genetic Association Studies Aged Aged 80 and over General Immunology and Microbiology business.industry digestive oral and skin physiology Case-control study General Medicine Middle Aged medicine.disease Obesity Logistic Models Suppressor of Cytokine Signaling 3 Protein Case-Control Studies Immunology Hypertension Female Gene polymorphism medicine.symptom business Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2021 (2021) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Endothelial inflammation and vascular damage are essential risk factors contributing to hypertension. Suppressor of cytokine signaling 3 (SOCS3) is involved in the regulation of multiple inflammatory pathways. A large number of studies have shown that the anti-inflammatory effect of SOCS3 in hypertension, obesity, and allergic reactions has brought more insights into the inhibition of inflammation. Therefore, we selected a tagSNP of SOCS3 (rs8064821) to investigate whether they are contributing to the risk of hypertension in the Chinese population. In total, 532 patients with hypertension and 569 healthy controls were enrolled for two central of China. SOCS3 rs8064821 C>A polymorphism was genotyped using TaqMan assay. SOCS3 rs8064821 CA genotype was associated with an increased risk of hypertension ( OR = 1.821 , 95 % CI = 1.276 -2.600, P = 0.001 ). Rs8064821 A allele was associated with higher SOCS3 mRNA level in PBMCs from healthy donors. SOCS3 rs8064821 C>A polymorphism may contribute to the risk of hypertension in the Chinese population by regulating the expression of SOCS3. |
| Databáze: | OpenAIRE |
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