| Autor: |
M.I. Choudhary, B.A. Ayinde, R.O. Imade, A. Alam |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Nigerian Journal of Natural Products and Medicine; Vol. 25 No. 1 (2021); 60-63 |
| ISSN: |
1118-6267 |
| DOI: |
10.4314/njnpm.v25i1.5 |
| Popis: |
Zingiber officinale rhizome is used in ethnomedicine in treating tumor-related ailments. This study was undertaken to evaluate the cytotoxic effects of this plant. The oil was extracted using a Clavenger apparatus by hydro-distillation method. Preliminary screening was carried out with brine shrimp cytotoxicity test at 10-1000 µg/mL. The volatile oil was further tested on breast cancer (AU 565) and cervical cancer (HeLa) at 50 µg /mL using MTT assay and later subjected to GCMS analysis. LC50 of 157.75 µg/mL was obtained in the brine shrimp mortality assay. Z. officinale oil showed high anticancer activities with 50 and 43 % inhibitions against HeLa and AU 565 cells respectively. GCMS analysis revealed the major constituents of Z. officinale oil as a-citral (11.68 %) and a-citral (10.18 %). These results suggest the medicinal potency of this plant oil. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
