An update on the epigenetics of glioblastomas
| Autor: | Bárbara do Nascimento Borges, Carlos Antonio da Costa Junior, Mariceli Baia Leão Barros, Thamirys Aline Silva Faro, Rommel Rodríguez Burbano, Maria Lúcia Harada, Danilo do Rosário Pinheiro, Adriana Corrêa de Souza Teixeira, Mariana Diniz Araújo, Wallax Augusto Silva Ferreira, Symara Rodrigues-Antunes, Edivaldo Herculano Corrêa de Oliveira |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Brain tumor medicine.disease_cause Bioinformatics Epigenesis Genetic Targeted therapy 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Genetics medicine Humans Epigenetics biology Brain Neoplasms Cancer medicine.disease nervous system diseases Gene Expression Regulation Neoplastic 030104 developmental biology Histone 030220 oncology & carcinogenesis DNA methylation biology.protein Glioblastoma Carcinogenesis Epigenetic therapy |
| Zdroj: | Epigenomics. 8:1289-1305 |
| ISSN: | 1750-192X 1750-1911 |
| DOI: | 10.2217/epi-2016-0040 |
| Popis: | Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment. |
| Databáze: | OpenAIRE |
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