| Autor: |
Nico Golfrè Andreasi, Roberto Cilia, Luigi Michele Romito, Salvatore Bonvegna, Giulia Straccia, Antonio Emanuele Elia, Alessio Novelli, Giuseppe Messina, Giovanni Tringali, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Valentina Gasparini, Marina Grisoli, Mario Stanziano, Francesco Ghielmetti, Sara Prioni, Elisa Bocchi, Paolo Amami, Sylvie Hélène Marie Jeanne Piacentini, Elisa Francesca Maria Ciceri, Maria Grazia Bruzzone, Roberto Eleopra |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Movement disorders : official journal of the Movement Disorder SocietyReferences. 37(11) |
| ISSN: |
1531-8257 |
| Popis: |
Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy is a safe and effective procedure for drug-resistant tremor in Parkinson's disease (PD).The aim of this study was to demonstrate that MRgFUS ventralis intermedius thalamotomy in early-stage tremor-dominant PD may prevent an increase in dopaminergic medication 6 months after treatment compared with matched PD control subjects on standard medical therapy.We prospectively enrolled patients with early-stage PD who underwent MRgFUS ventralis intermedius thalamotomy (PD-FUS) and patients treated with oral dopaminergic therapy (PD-ODT) with a 1:2 ratio. We collected demographic and clinical data at baseline and 6 and 12 months after thalamotomy.We included 10 patients in the PD-FUS group and 20 patients in the PD-ODT group. We found a significant increase in total levodopa equivalent daily dose and levodopa plus monoamine oxidase B inhibitors dose in the PD-ODT group 6 months after thalamotomy.In early-stage tremor-dominant PD, MRgFUS thalamotomy may be useful to reduce tremor and avoid the need to increase dopaminergic medications. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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