Subcortical short‐term plasticity elicited by deep brain stimulation
| Autor: | Harrison C. Walker, Sarah D. Black, Ryan J. Vaden, Byron C. Jaeger, Zachary T. Irwin, Barton L. Guthrie, J. Nicole Bentley, Arie Nakhmani, Mohammad Z. Awad, Christopher L. Gonzalez |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Deep brain stimulation Deep Brain Stimulation Essential Tremor medicine.medical_treatment Neural facilitation Neurosciences. Biological psychiatry. Neuropsychiatry Local field potential Stimulus (physiology) Globus Pallidus 03 medical and health sciences 0302 clinical medicine Subthalamic Nucleus Neuroplasticity Humans Medicine Latency (engineering) RC346-429 Research Articles Aged Aged 80 and over Ventral Thalamic Nuclei Neuronal Plasticity business.industry General Neuroscience Interstimulus interval Parkinson Disease Middle Aged Electrophysiological Phenomena Electrophysiology 030104 developmental biology Female Neurology. Diseases of the nervous system Electrocorticography Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery RC321-571 Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 8, Iss 5, Pp 1010-1023 (2021) |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.51275 |
| Popis: | Objective To investigate local short‐term neuroplasticity elicited by subthalamic, thalamic, and pallidal deep brain stimulation (DBS) for movement disorders. Methods During DBS surgery, we delivered pairs of stimulus pulses with both circular and directional leads across 90 interstimulus intervals in 17 participants and recorded local field potentials from unused contacts on the implanted electrode array. We removed the stimulus artifact, validated the neural origin of the underlying signals, and examined short‐term plasticity as a function of interstimulus interval and DBS target, using linear mixed effects models. Results DBS evokes short latency local field potentials that are readily detected with both circular and directional leads at all stimulation targets (0.31 ± 0.10 msec peak latency, mean ± SD). Peak amplitude, area, and latency are modified strongly by interstimulus interval (P |
| Databáze: | OpenAIRE |
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