Bipolar depressed patients show both failure to activate and failure to de-activate during performance of a working memory task
| Autor: | Salvador Sarró, Benedikt L. Amann, Gemma C. Monté, Paloma Fernández-Corcuera, Edith Pomarol-Clotet, Raymond Salvador, Jordi Ortiz-Gil, Bibiana Sans-Sansa, Noemi Moro, Teresa Maristany, Eduard Vieta, Peter J. McKenna, Jose Manuel Goikolea |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Cerebellum Elementary cognitive task Bipolar Disorder Prefrontal Cortex Audiology behavioral disciplines and activities Task (project management) Task Performance and Analysis medicine Humans Prefrontal cortex Psychiatry Default mode network Depression (differential diagnoses) Working memory Middle Aged Magnetic Resonance Imaging Dorsolateral prefrontal cortex Psychiatry and Mental health Clinical Psychology Memory Short-Term medicine.anatomical_structure Case-Control Studies Female Psychology |
| Zdroj: | Journal of Affective Disorders. 148:170-178 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2012.04.009 |
| Popis: | Background Bipolar depression has been found to be associated with changes in prefrontal cortex activity during performance of cognitive tasks. However, the role of task-related de-activations has been little investigated. Method Forty-one bipolar depressed patients and 41 matched normal controls underwent fMRI scanning while performing baseline, 1-back and 2-back versions of the n-back task. Linear models were used to obtain maps of within-group activations and areas of differential activation between the groups. Results The bipolar depressed patients showed reduced activation in the dorsolateral prefrontal cortex (DLPFC) bilaterally and several other regions. After controlling for differences in task performance only differences in the DLPFC and cerebellum remained. Left DLPFC activation was inversely correlated with Hamilton and MADRS scores. The patients showed failure to de-activate in the medial prefrontal cortex, an area corresponding to the anterior medial node of the default mode network. Limitations To confirm default mode network dysfunction demonstration of resting-state connectivity abnormalities would also be required. The study was carried out on treated patients, and did not assess for presence of depressive symptoms in the healthy controls. Conclusions Both prefrontal cortical and default mode network dysfunction appear to characterise bipolar depression. The former, but not the latter, is associated with symptom severity. |
| Databáze: | OpenAIRE |
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