DNA repair gene ERCC2 polymorphisms and associations with breast and ovarian cancer risk
| Autor: | Luc Fontana, Nadège Rabiau, Nasséra Chalabi, Rémy Bosviel, Samir Satih, Alain Chamoux, Yves-Jean Bignon, Dominique Bernard-Gallon, Laetitia Delort, Fabrice Kwiatkowski |
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| Přispěvatelé: | Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER, Nutrition, Cancérogenèse et Thérapie anti-tumorale, Université d'Auvergne - Clermont-Ferrand I (UdA), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Clermont Université, Université Jean Monnet - Saint-Étienne (UJM), Institut de Médecine du Travail, CHU Clermont-Ferrand-Université d'Auvergne - Clermont-Ferrand I (UdA), Qualité des Produits Animaux (QuaPA), Institut National de la Recherche Agronomique (INRA), Laboratoire de Pharmacognosie / Biotechnologies (UMR484) |
| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
DNA Repair Genotype DNA repair Population [SDV.CAN]Life Sciences [q-bio]/Cancer Breast Neoplasms Single-nucleotide polymorphism Biology Bioinformatics Polymorphism Single Nucleotide lcsh:RC254-282 Breast cancer Gene Frequency Risk Factors Odds Ratio medicine Genetic predisposition Humans Genetic Predisposition to Disease education Xeroderma Pigmentosum Group D Protein Ovarian Neoplasms Genetics education.field_of_study Polymorphism Genetic Research lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Penetrance Oncology Molecular Medicine ERCC2 Female |
| Zdroj: | Molecular Cancer, Vol 7, Iss 1, p 36 (2008) Molecular Cancer Molecular Cancer, 2008, 7, ⟨10.1186/1476-4598-7-36⟩ |
| ISSN: | 1476-4598 |
| DOI: | 10.1186/1476-4598-7-36 |
| Popis: | Breast and ovarian cancers increased in the last decades. Except rare cases with a genetic predisposition and high penetrance, these pathologies are viewed as a polygenic disease. In this concept, association studies look for genetic variations such as polymorphisms in low penetrance genes,i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damages have been shown to have significantly reduced. In particular, enzymes of the nucleotide excision repair pathway are suspected to be implicated in cancer. In this study, 2 functional polymorphisms in a DNA repair geneERCC2were analyzed. The population included 911 breast cancer cases, 51 ovarian cancer cases and 1000 controls. The genotyping of 2 SNP (Single Nucleotide Polymorphism) was carried out on the population with the MGB (Minor Groove Binder) probe technique which consists of the use of the allelic discrimination with the Taqman®method. This study enabled us to show an increase in risk of breast cancer with no oral contraceptive users and with women exhibiting a waist-to-hip ratio (WHR) > 0.85 for Asn homozygous forERCC2 312. |
| Databáze: | OpenAIRE |
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