Selegiline Transdermal System: An Examination of the Potential for CYP450-Dependent Pharmacokinetic Interactions With 3 Psychotropic Medications
| Autor: | Bryan J. Campbell, John Ziemniak, Chad M. VanDenBerg, Eva M. Kemper, Albert J. Azzaro |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Monoamine Oxidase Inhibitors medicine.drug_class Cmax Pharmacology Bioequivalence Administration Cutaneous Benzodiazepines Cytochrome P-450 Enzyme System Pharmacokinetics Selegiline medicine Humans Drug Interactions Pharmacology (medical) Transdermal Monoamine oxidase inhibitor Cross-Over Studies Alprazolam business.industry Risperidone Crossover study Antidepressive Agents Anti-Anxiety Agents Olanzapine Anesthesia Female business Antipsychotic Agents medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 47:146-158 |
| ISSN: | 0091-2700 |
| DOI: | 10.1177/0091270006296151 |
| Popis: | Selegiline transdermal system (STS) is a recently approved monoamine oxidase inhibitor antidepressant. This article reports results from 3 studies examining the potential for cytochrome P450-dependent pharmacokinetic interactions between STS and 3 psychotropic medications that might be coadministered. Three open-label, randomized, Latin square, 3-sequence crossover design studies were conducted with healthy volunteers to determine the pharmacokinetic parameters of STS 6 mg/24 h and test drug (alprazolam, olanzapine, or risperidone) when administered alone and concomitantly. All pharmacokinetic parameters of interest were unaltered following selegiline or test drug monotherapy when compared to concomitant therapy. This was confirmed by least squares mean ratios and their 90% confidence intervals of log(e)-transformed C(max) and AUC(tau) values, using either standard bioequivalence criteria of 80% to 125% or study-defined 70% to 143% boundary criteria. These results demonstrate that STS 6 mg/24 h may provide an antidepressant option that is unlikely to result in CYP450-mediated pharmacokinetic drug-drug interactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text