A pH-responsive supramolecular polymer gel as an enteric elastomer for use in gastric devices
| Autor: | Veronica A. Montgomery, Dean L. Glettig, Ross Barman, Landon D. Nash, Andrew Bellinger, Jiahua Zhu, Cody Cleveland, Robert Langer, Giovanni Traverso, Li Gu, Duncan J. Maitland, Young-Ah Lucy Lee, Shiyi Zhang |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
Polymers Swine Nanotechnology 02 engineering and technology 010402 general chemistry Elastomer 01 natural sciences Nutritional modulation Article Dosage form Drug Delivery Systems Esophagus Animals Humans Technology Pharmaceutical General Materials Science Gastrointestinal Transit chemistry.chemical_classification Extramural Mechanical Engineering Stomach digestive oral and skin physiology General Chemistry Polymer Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Supramolecular polymers Safety profile Elastomers chemistry Mechanics of Materials Electronics 0210 nano-technology Gels Tablets Large animal |
| Zdroj: | Nature materials |
| ISSN: | 1476-4660 1476-1122 |
| Popis: | Devices resident in the stomach -- which are used for a variety of clinical applications including nutritional modulation for bariatrics, ingestible electronics for diagnosis and monitoring, and gastric retentive dosage forms for prolonged drug delivery -- typically incorporate elastic polymers to compress the devices during delivery through the esophagus and other narrow orifices in the digestive system. However, in the event of accidental device fracture or migration, the non-degradable nature of these materials risks intestinal obstruction. Here, we show that an elastic, pH-responsive supramolecular gel remains stable and elastic in the acidic environment of the stomach but can be dissolved in the neutral-pH environment of the small and large intestines. In a large animal model, prototype devices with these materials as the key component demonstrated prolonged gastric retention and safe passage. These enteric elastomers should increase the safety profile for a wide range of gastric retentive devices. |
| Databáze: | OpenAIRE |
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