Familial aggregation analysis of cognitive performance in early-onset bipolar disorder
| Autor: | Sara Lera-Miguel, Panagiotis Ferentinos, Lourdes Fañanás, Rosa Calvo, Luisa Lázaro, Jordi Vallespir Soler, Mar Fatjó-Vilas |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Adolescent Offspring 03 medical and health sciences 0302 clinical medicine Cognition Developmental and Educational Psychology Child and adolescent psychiatry Medicine Humans 0501 psychology and cognitive sciences Family Effects of sleep deprivation on cognitive performance Bipolar disorder Early onset business.industry Working memory 05 social sciences Family aggregation General Medicine Middle Aged Executive functions medicine.disease 030227 psychiatry Psychiatry and Mental health Pediatrics Perinatology and Child Health Female business 050104 developmental & child psychology Clinical psychology |
| Zdroj: | European childadolescent psychiatry. 29(12) |
| ISSN: | 1435-165X |
| Popis: | We analysed the familial aggregation (familiality) of cognitive dimensions and explored their role as liability markers for early-onset bipolar disorder (EOBD). The sample comprised 99 subjects from 26 families, each with an offspring diagnosed with EOBD. Four cognitive dimensions were assessed: reasoning skills; attention and working memory; memory; and executive functions. Their familiality was investigated in the total sample and in a subset of healthy relatives. The intra-family resemblance score (IRS), a family-based index of the similarity of cognitive performance among family members, was calculated. Familiality was detected for the attention and working memory (AW) dimension in the total sample (ICC = 0.37, p = 0.0004) and in the subsample of healthy relatives (ICC = 0.37, p = 0.016). The IRS reflected that there are families with similar AW mean scores (either high or low) and families with heterogeneous scores. Families with the most common background for the AW dimension (IRS > 0) were selected and dichotomized in two groups according to the mean family AW score. This allowed differentiating families whose members had similar high scores than those with similar low scores: both patients (t = − 4.82, p = 0.0005) and relatives (t = − 5.04, p |
| Databáze: | OpenAIRE |
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