Vitamin D Regulates Maternal T-Helper Cytokine Production in Infertile Women
| Autor: | Koji Nakagawa, Makoto Jinushi, Yuko Ikemoto, Keiji Kuroda, Rikikazu Sugiyama, Rie Ozaki, Keisuke Murakami, Asako Ochiai, Akemi Matsumoto, Satoru Takeda |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Time Factors medicine.medical_treatment Cell vitamin D Endometrium 0302 clinical medicine Interferon Clinical efficacy Prospective Studies Th1-Th2 Balance Cells Cultured Cholecalciferol preconception care 030219 obstetrics & reproductive medicine Nutrition and Dietetics Interleukin medicine.anatomical_structure Cytokine Treatment Outcome helper T cell Cytokines Female infertility Infertility Female lcsh:Nutrition. Foods and food supply medicine.drug Infertility Adult medicine.medical_specialty Primary Cell Culture lcsh:TX341-641 Article 03 medical and health sciences Th2 Cells Internal medicine medicine Vitamin D and neurology Humans Calcifediol Pregnancy business.industry Th1 Cells medicine.disease Vitamin D Deficiency 030104 developmental biology Endocrinology Dietary Supplements Stromal Cells business Biomarkers Food Science |
| Zdroj: | Nutrients Volume 10 Issue 7 Nutrients, Vol 10, Iss 7, p 902 (2018) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu10070902 |
| Popis: | Vitamin D (VD) deficiency is associated with reproductive failure. However, the relationship between VD and maternal immunity remains unclear. We investigated the clinical efficacy of VD in maternal T-helper (Th) cytokines in 276 infertile women and examined for Th1 and Th2 cells based on the deficient, insufficient, and sufficient serum 25-hydroxyvitamin D3 (25[OH]VD) levels (< 12, 12&ndash 30, and > 30 ng/mL, respectively). Most infertile women had a low-level of VD (87.3%). Immunological tests of pre-/post-VD supplementation were performed in patients who were deficient and insufficient in VD. Of 23 patients, 11 (47.8%) exhibited sufficient VD levels after supplementation. Th1/Th2 cell ratio in patients with insufficient VD was significantly decreased after supplementation (p = 0.004). After supplementation, serum 25(OH)VD levels of the patients: 11 in the sufficient group showed significant decreases in Th1 cell level and Th1/Th2 cell ratio (p = 0.032 and 0.010, respectively), whereas no significant differences in Th1/Th2 cell ratio were recognized in the insufficient group. Furthermore, mid-luteal endometrial biopsies (n = 18) were processed for primary cultures and measured interferon [IFN]-&gamma and interleukin [IL]-4 in condition media. Decidualizing cultures with 1,25-dihydroxvitamin D3 (1,25[OH]2VD) decreased IFN-&gamma Sufficient VD supplementation in women with insufficient VD may optimize maternal T-helper cytokines during pregnancy via rebalancing the Th1/Th2 cell ratio. |
| Databáze: | OpenAIRE |
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