Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee
| Autor: | D. Muelheims, A. Goldmann, Goetz H. Welsch, S.T. Soellner, Milena L Pachowsky |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Cartilage Articular Male medicine.medical_specialty Adolescent Knee Joint Biomedical Engineering Osteoarthritis Knee Injuries 030218 nuclear medicine & medical imaging 03 medical and health sciences Arthroscopy Young Adult 0302 clinical medicine Rheumatology medicine Humans Orthopedics and Sports Medicine Prospective Studies Prospective cohort study Rank correlation Aged 030203 arthritis & rheumatology medicine.diagnostic_test Receiver operating characteristic business.industry Cartilage Magnetic resonance imaging Middle Aged Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Sagittal plane medicine.anatomical_structure Female Radiology business |
| Zdroj: | Osteoarthritis and cartilage. 25(11) |
| ISSN: | 1522-9653 |
| Popis: | Summary Objective The aim of this study was to compare T2 relaxation times of knee cartilage with intraoperative results for the assessment of early osteoarthritis (OA) and to define T2 values for the differentiation between healthy and degenerated cartilage. Design Twenty-one patients with cartilage lesions or moderate OA were examined using 3T magnetic resonance imaging (MRI). In this prospective study, a total of 882 regions of interest (ROIs) were examined by a sagittal, multi-echo, spin-echo T2 sequence and a morphological high-resolution three-dimensional, fat-saturated proton-density space sequence. Cartilage lesions were identified arthroscopically, graded by the International Cartilage Repair Society (ICRS) score in 42 defined ROIs per patient and consecutively compared with mean T2 values using analysis of variance and Spearman's rank correlation test. Receiver operating characteristics (ROC) curves were developed to identify threshold T2 values to differentiate between the ICRS grades. Results A total of 882 ROIs were examined and graduated in ICRS score 0 (67.3%), 1 (25.2%), 2 (6.2%) and the merged ICRS 3 and 4 (1.0%). T2 values increased with increasing grade of cartilage damage with a statistically significant positive correlation between T2 values and ICRS scores. A T2 value threshold of 47.6 ms was identified to differentiate between ICRS score 0 (normal) and all other grades (ROC curve analysis). Conclusion T2 mapping might provide a diagnostic tool for the detection of early knee-joint cartilage damage and for the non-invasive differentiation between ICRS grades by MRI in clinical practice. |
| Databáze: | OpenAIRE |
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