Serum immunoglobulin free light chain correlates with tumor burden markers in Waldenstrom macroglobulinemia
| Autor: | Xavier Leleu, Sophie Dupire, Daniela Robu, Irene M. Ghobrial, Renee Leduc, Steven P. Treon, Aldo M. Roccaro, Nicholas Burwick, Thierry Facon, Edie Weller, Anne Moreau, Vale Rie Coiteux, Robert Manning, Bernadette Hennache, Marybeth Nelson, Evdoxia Hatjiharissi, Stéphane Darre, Morie A. Gertz |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Tumor burden Paraproteinemias Disease Immunoglobulin light chain Hemoglobins Internal medicine medicine Biomarkers Tumor Humans Survival rate Aged Aged 80 and over biology business.industry Waldenstrom macroglobulinemia International Agencies Hematology Middle Aged medicine.disease Prognosis Survival Rate Immunoglobulin M Tumor progression Immunology biology.protein Female Immunoglobulin Light Chains Antibody Waldenstrom Macroglobulinemia business beta 2-Microglobulin |
| Zdroj: | Leukemialymphoma. 49(6) |
| ISSN: | 1029-2403 |
| Popis: | The serum IgM level has been utilised as a marker of tumor progression and to assess response to therapy in patients with Waldenstrom macroglobulinemia (WM). However, there are many limitations to the IgM protein level. The objective of this study was to evaluate the association of known tumor burden markers and prognostic factors with serum free light chain (sFLC) in 98 patients with WM. We demonstrated that sFLC measurement accurately differentiated IgM-MGUS compared with WM reflecting a measurement of tumor burden. In univariate and multivariate analysis, median sFLC at the cut-off at 60 mg/L was higher for WM patients with low hemoglobin and high beta2M, when we applied the WM-IPSS cut-offs, but showed no association with IgM level. This study demonstrates that sFLC is a new marker in WM disease. Further analysis is required to prospectively study the role of sFLC in monitoring response to therapy and as a prognostic marker in WM patients. |
| Databáze: | OpenAIRE |
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