Increased hydrazine excretion associated with systemic lupus erythematosus
| Autor: | Shudo Nishigouri, Shiro Kameda, Masaya Yamaguchi, Toshiyuki Yanase, Kenji Tanaka, Kenji Matsuyama, Kenji Kajiyama, Shozaburo Jimi, Sadao Iguchi |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Metabolite Immunology Population Pathology and Forensic Medicine Excretion chemistry.chemical_compound Urinary excretion Japan immune system diseases Internal medicine Isoniazid Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic Hydrazine (antidepressant) skin and connective tissue diseases education Saliva education.field_of_study business.industry Acetylation Middle Aged Endocrinology Hydrazines chemistry Female business medicine.drug |
| Zdroj: | Clinical immunology and immunopathology. 22(1) |
| ISSN: | 0090-1229 |
| Popis: | Thirty patients with systemic lupus erythematosus (SLE) were given isoniazid (INH) and their acetylation phenotypes determined. Of 30 patients, 2 were slow acetylators (7%), 28 rapid acetylators. This was approximately equivalent to the ratio in the control group (12%) and to the prevalence in the general population (10%). Urinary excretion of the metabolite hydrazine was determined in 10 SLE patients and 9 controls. The significantly higher hydrazine excretion from SLE patients as compared with that from controls suggested an aberration of metabolism in the SLE patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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