Fornix Microstructure Correlates with Recollection But Not Familiarity Memory
| Autor: | Heidi Johansen-Berg, Andy C. H. Lee, Sarah R. Rudebeck, Jan Scholz, Rebecca Millington, Gustavo Rohenkohl |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Mammillary Bodies Mammillary body Fornix Brain Hippocampus Neuropsychological Tests Brain mapping Article Temporal lobe Young Adult Cognition Memory Reference Values Neural Pathways Humans Diencephalon Episodic memory Brain Mapping Anthropometry Recall General Neuroscience Fornix Recognition Psychology Magnetic Resonance Imaging eye diseases Anterior Thalamic Nuclei nervous system Female sense organs Psychology Neuroscience Photic Stimulation psychological phenomena and processes |
| Zdroj: | The Journal of Neuroscience. 29:14987-14992 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | The fornix is the main tract between the medial temporal lobe (MTL) and medial diencephalon, both of which are critical for episodic memory. The precise involvement of the fornix in memory, however, has been difficult to ascertain since damage to this tract in human amnesics is invariably accompanied by atrophy to surrounding structures. We used diffusion-weighted imaging to investigate whether individual differences in fornix white matter microstructure in neurologically healthy participants were related to differences in memory as assessed by two recognition tasks. Higher microstructural integrity in the fornix tail was found to be associated with significantly better recollection memory. In contrast, there was no significant correlation between fornix microstructure and familiarity memory or performance on two non-mnemonic tasks. Our findings support the idea that there are distinct MTL–diencephalon pathways that subserve differing memory processes. |
| Databáze: | OpenAIRE |
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