The expression of interferon receptor α/β in human pancreatic cancer in nude mice is essential for tumor response to interferon α treatment
| Autor: | Jacqueline Tilak, ILKe Nalbantoglu, Reza F. Saidi, Michael J. Jacobs, Ahmad Ahad |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Antimetabolites Antineoplastic medicine.medical_treatment Mice Nude Receptor Interferon alpha-beta Deoxycytidine Mice In vivo Interferon Pancreatic cancer Cell Line Tumor medicine Animals Humans Immunologic Factors Receptor business.industry Carcinoma Interferon-alpha medicine.disease Gemcitabine Pancreatic Neoplasms Regimen Cell culture Cancer research Surgery business Adjuvant medicine.drug |
| Zdroj: | The Journal of surgical research. 173(2) |
| ISSN: | 1095-8673 |
| Popis: | Adjuvant interferon based chemoradiation has rendered promising results against pancreatic cancer. This study evaluated the in vivo effect of interferon α on two human pancreatic carcinoma cell lines implanted in nude.MiaPaCa-2 expressed the interferon α/β receptor and Panc-1 cells did not. Regimen I consisted of intraperitoneal single-agent gemcitabine and Regimen II consisted of IFN-α and gemcitabine biweekly for 30 d.Regimen I and II significantly decreased median tumor volume compared with control mice (P0.001). However, MiaPaCa-2 showed a more dramatic response to Regimen II compared with Panc-1 implanted mice. MiaPaCa-2 and treated with Regimen II showed less metastasis and less local invasion compared with Panc-1 treated with same regimen. Regimen II was more effective on MiaPaCa-2 compared with Regimen I (P0.001). There were no differences between Regimens I and II in the Panc-1 group.Treatment of human pancreatic cancer in nude mice with interferon α and gemcitabine was associated with a reduction in tumor volume. This process was more prominent in the cells that express the interferon receptors. |
| Databáze: | OpenAIRE |
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