Plasma YKL-40: a Potential Biomarker for Tumor Invasion in Esophageal Cancer
| Autor: | Jiangyi Liu, Rongfu Huang, Huiming Ye, Jianfeng Yao, Hongbin Duan, Chunmei Fan, Xin Ding |
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| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Esophageal Neoplasms Gastroenterology Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology Young Adult Internal medicine medicine Biomarkers Tumor Humans Clinical significance Neoplasm Invasiveness Chitinase-3-Like Protein 1 Thrombus Young adult Tumor marker Aged Retrospective Studies Receiver operating characteristic business.industry Retrospective cohort study Esophageal cancer Middle Aged medicine.disease Lymphatic Metastasis Biomarker (medicine) Female business |
| Zdroj: | Clinical laboratory. 66(3) |
| ISSN: | 1433-6510 |
| Popis: | Background YKL-40, a chitinase-like glycoprotein has been identified as a candidate tumor marker. The current study evaluated the clinical significance of plasma YKL-40 in esophageal cancer patients. Methods We enrolled 127 esophageal cancer patients, 29 healthy controls. Plasma YKL-40 levels were measured through enzyme linked immunosorbent assay. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic efficiency of plasma YKL-40 in esophageal cancer patients. The correlations between plasma YKL-40 and clinicopathological characteristics of esophageal were analyzed. Results Plasma YKL-40 levels were significantly higher in patients with lymph node metastasis than those that were non-metastatic (p = 0.005). Patients with tumor thrombus formation presented with significantly higher YKL-40 levels than those without thrombus formation (160.3 vs. 74.7 ng/mL, p = 0.012). YKL-40 levels in patients with advanced stage (III and IV) were significantly higher than those in the early stages (I and II, p = 0.016). ROC curve analysis showed that the area under curve was 0.909, and the best diagnostic threshold of YKL-40 for esophageal cancer was 80.6 ng/mL with 68.9% sensitivity and 96.6% specificity. Conclusions This study indicated that YKL-40 may be a biomarker for esophageal cancer and potential biomarker for identification of invasive esophageal cancer. |
| Databáze: | OpenAIRE |
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