Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent
| Autor: | Noorjahan Banu Alitheen, Kim Wei Chan, Hairuszah Ithnin, Der Jiun Ooi, Maznah Ismail, Nadarajan Sarega |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant ethyl acetate fraction medicine.medical_treatment Molineria latifolia rhizome Pharmaceutical Science antioxidant activity curculigoside-cinnamic acid-rich fraction oxidative stress 3T3-L1 preadipocytes Oxidative phosphorylation medicine.disease_cause Benzoates Cinnamic acid Antioxidants Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound Mice lcsh:Organic chemistry Glucosides Phenols Picrates Glycation 3T3-L1 Cells Drug Discovery medicine Animals Food science Physical and Theoretical Chemistry Curculigoside Flavonoids Chemistry Plant Extracts Organic Chemistry Rhizome Oxidative Stress 030104 developmental biology Biochemistry Chemistry (miscellaneous) Cinnamates Molecular Medicine Hypoxidaceae Oxidation-Reduction Oxidative stress |
| Zdroj: | Molecules Molecules; Volume 21; Issue 6; Pages: 682 Molecules, Vol 21, Iss 6, p 682 (2016) |
| ISSN: | 1420-3049 |
| Popis: | Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads to obesity-associated metabolic syndrome. Strategies for the restoration of redox balance, potentially by exploring potent plant bioactives, have thus become the focus of therapeutic intervention. The present study aimed to bioprospect the potential use of the curculigoside-cinnamic acid-rich fraction from Molineria latifolia rhizome as an antioxidant therapeutic agent. The ethyl acetate fraction (EAF) isolated from M. latifolia rhizome methanolic extract (RME) contained the highest amount of phenolic compounds, particularly curculigoside and cinnamic acid. EAF demonstrated glycation inhibitory activities in both glucose- and fructose-mediated glycation models. In addition, in vitro chemical-based and cellular-based antioxidant assays showed that EAF exhibited high antioxidant activities and a protective effect against oxidative damage in 3T3-L1 preadipocytes. Although the efficacies of individual phenolics differed depending on the structure and concentration, a correlational study revealed strong correlations between total phenolic contents and antioxidant capacities. The results concluded that enriched phenolic contents in EAF (curculigoside-cinnamic acid-rich fraction) contributed to the overall better reactivity. Our data suggest that this bioactive-rich fraction warrants therapeutic potential against oxidative stress-related disorders. |
| Databáze: | OpenAIRE |
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