The T-786C and C774T endothelial nitric oxide synthase gene polymorphisms independently affect the onset pattern of severe diabetic retinopathy
| Autor: | F. Elgrably, Henri Selmi, M. J. Taverna, Gérard Slama, J. L. Selam |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Genotype Nitric Oxide Synthase Type III Physiology Clinical Biochemistry Biochemistry Pathogenesis Enos Internal medicine Diabetes mellitus medicine Humans Age of Onset Type 1 diabetes Diabetic Retinopathy Polymorphism Genetic biology Case-control study Diabetic retinopathy Middle Aged medicine.disease biology.organism_classification Diabetes Mellitus Type 1 Endocrinology Case-Control Studies Female Nitric Oxide Synthase Age of onset |
| Zdroj: | Nitric Oxide. 13:88-92 |
| ISSN: | 1089-8603 |
| DOI: | 10.1016/j.niox.2005.04.004 |
| Popis: | Genetic factors could be implicated in the pathogenesis of severe diabetic retinopathy (DR). Recently, we reported a strong association between the eNOS4b/a endothelial nitric oxide synthase (eNOS) polymorphism and severe DR. To examine whether T-786C and C774T eNOS polymorphisms are involved in severe DR, 254 Caucasians with longstanding C-peptide-negative type 1 diabetes, 128 patients with absent/mild DR (control group), and 126 patients with preproliferative/proliferative DR (study group) were genotyped. The distribution of T-786C and C774T eNOS polymorphisms was in Hardy-Weinberg equilibrium and did not differ between the study and control groups. However, in case patients (n=126), T-786C and C774T polymorphisms influenced the onset pattern of severe DR (P=0.0169 and P=0.0257, respectively). The C-786C genotype was associated with early-onset severe DR (duration of diabetes: 15.2+/-5.9 vs. 19.4+/-6.3 years, P=0.0105), and the homozygous T774T genotype was associated with late-onset severe DR (24.3+/-7.0 vs. 18.4+/-6.2 years, P=0.0067). In the case of patients with high glycosylated hemoglobin levels (HbA1c >8%, n=88), the association between the T-786C polymorphism and early-onset severe DR was stronger (P=0.0068). Case patients carrying the C-786C genotype had higher HbA1c values (9.61+/-1.89%) than those carrying the T-786T genotype (8.93+/-1.47%, P=0.0173). Multivariate analysis showed that T-786C polymorphism was the best independent factor for onset pattern of severe DR (P |
| Databáze: | OpenAIRE |
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