Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice
| Autor: | Lo Sheng-Nan, Lee Shih-Ying, Ruei-Min Lu, I-Ju Liu, Chen-Hsien Liang, Chih-Hsien Chang, Liang-Cheng Chen, Wei-Lin Lo, Han-Chung Wu, Ming-Wei Chen |
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| Rok vydání: | 2020 |
| Předmět: |
Biodistribution
Breast Neoplasms Gallium Radioisotopes Peptide Mice SCID 010403 inorganic & nuclear chemistry Multimodal Imaging digestive system 01 natural sciences 030218 nuclear medicine & medical imaging Heterocyclic Compounds 1-Ring Mice 03 medical and health sciences 0302 clinical medicine Breast cancer Mice Inbred NOD Cell Line Tumor medicine Animals Humans Tissue Distribution neoplasms chemistry.chemical_classification Radiation Chemistry Indium Radioisotopes medicine.disease Xenograft Model Antitumor Assays In vitro 0104 chemical sciences Diagnostic agent Cancer cell Cancer research Female Radiopharmaceuticals Ct imaging Oligopeptides |
| Zdroj: | Applied Radiation and Isotopes. 161:109162 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/j.apradiso.2020.109162 |
| Popis: | The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients. |
| Databáze: | OpenAIRE |
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