Regulation of the cardiac sodium pump
| Autor: | William Fuller, Lindsay B. Tulloch, Sarah Calaghan, Jacqueline Howie, Krzysztof J. Wypijewski, Michael J. Shattock |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cardiac function curve
Models Molecular Sodium Sodium-Potassium-Exchanging ATPase Molecular Sequence Data Phospholemman chemistry.chemical_element Review 030204 cardiovascular system & hematology Nitric Oxide 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Protein kinase A Protein kinase C FXYD medicine Myocyte Animals Humans Amino Acid Sequence Na+/K+-ATPase Phosphorylation Molecular Biology Sodium pump Ion transporter 030304 developmental biology Ion transport Pharmacology 0303 health sciences Myocardium Cardiac muscle Membrane Proteins Heart Cell Biology Phosphoproteins Cyclic AMP-Dependent Protein Kinases Cell biology Intracellular sodium medicine.anatomical_structure chemistry Biochemistry Molecular Medicine Protein Processing Post-Translational Sequence Alignment Palmitoylation |
| Zdroj: | Cellular and Molecular Life Sciences |
| ISSN: | 1420-9071 1420-682X |
| Popis: | In cardiac muscle, the sarcolemmal sodium/potassium ATPase is the principal quantitative means of active transport at the myocyte cell surface, and its activity is essential for maintaining the trans-sarcolemmal sodium gradient that drives ion exchange and transport processes that are critical for cardiac function. The 72-residue phosphoprotein phospholemman regulates the sodium pump in the heart: unphosphorylated phospholemman inhibits the pump, and phospholemman phosphorylation increases pump activity. Phospholemman is subject to a remarkable plethora of post-translational modifications for such a small protein: the combination of three phosphorylation sites, two palmitoylation sites, and one glutathionylation site means that phospholemman integrates multiple signaling events to control the cardiac sodium pump. Since misregulation of cytosolic sodium contributes to contractile and metabolic dysfunction during cardiac failure, a complete understanding of the mechanisms that control the cardiac sodium pump is vital. This review explores our current understanding of these mechanisms. Electronic supplementary material The online version of this article (doi:10.1007/s00018-012-1134-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink