Aging Alters Daily and Regional Calretinin Neuronal Expression in the Rat Non-image Forming Visual Thalamus
| Autor: | José Pablo G Queiroz, José Rodolfo Lopes de Paiva Cavalcanti, Jeferson S. Cavalcante, Felipe P Fiuza, Antônio Carlos Q. Aquino, Luiz Eduardo Mateus Brandão, Diego A. Câmara, Ramón H. Lima, Rovena C.G.J. Engelberth |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Aging Cognitive Neuroscience Thalamus Biology intergeniculate leaflet calcium binding proteins lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Calcium-binding protein Geniculate medicine Zeitgeber Circadian rhythm lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research calretinin aging ventral lateral geniculate nucleus Neurodegeneration Neurosciences lateral geniculate body medicine.disease 030104 developmental biology medicine.anatomical_structure circadian rhythms stereology Calretinin Nucleus Neuroscience Neurovetenskaper 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 13 (2021) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2021.613305 |
| Popis: | Aging affects the overall physiology, including the image-forming and non-image forming visual systems. Among the components of the latter, the thalamic retinorecipient inter-geniculate leaflet (IGL) and ventral lateral geniculate (vLGN) nucleus conveys light information to subcortical regions, adjusting visuomotor, and circadian functions. It is noteworthy that several visual related cells, such as neuronal subpopulations in the IGL and vLGN are neurochemically characterized by the presence of calcium binding proteins. Calretinin (CR), a representative of such proteins, denotes region-specificity in a temporal manner by variable day–night expression. In parallel, age-related brain dysfunction and neurodegeneration are associated with abnormal intracellular concentrations of calcium. Here, we investigated whether daily changes in the number of CR neurons are a feature of the aged IGL and vLGN in rats. To this end, we perfused rats, ranging from 3 to 24 months of age, within distinct phases of the day, namely zeitgeber times (ZTs). Then, we evaluated CR immunolabeling through design-based stereological cell estimation. We observed distinct daily rhythms of CR expression in the IGL and in both the retinorecipient (vLGNe) and non-retinorecipient (vLGNi) portions of the vLGN. In the ZT 6, the middle of the light phase, the CR cells are reduced with aging in the IGL and vLGNe. In the ZT 12, the transition between light to dark, an age-related CR loss was found in all nuclei. While CR expression predominates in specific spatial domains of vLGN, age-related changes appear not to be restricted at particular portions. No alterations were found in the dark/light transition or in the middle of the dark phase, ZTs 0, and 18, respectively. These results are relevant in the understanding of how aging shifts the phenotype of visual related cells at topographically organized channels of visuomotor and circadian processing. |
| Databáze: | OpenAIRE |
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