In vivo effects of curcumin on the paraoxonase, carbonic anhydrase, glucose-6-phosphate dehydrogenase and β-glucosidase enzyme activities in dextran sulphate sodium-induced ulcerative colitis mice

Autor:	Feray Köçkar, Selma Sinan, Fatma Bahar Sunay, Hatice Yildirim
Přispěvatelé:	Fen Edebiyat Fakültesi
Rok vydání:	2016
Předmět:	0301 basic medicine Curcumin Pharmacology Glucosephosphate Dehydrogenase Inflammatory bowel disease 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine In vivo Carbonic anhydrase Drug Discovery medicine Ulcerative Colitis Glucose-6-phosphate dehydrogenase Animals chemistry.chemical_classification Mice Inbred BALB C biology Aryldialkylphosphatase beta-Glucosidase Inflammatory Bowel Disease Dextran Sulfate Paraoxonase General Medicine medicine.disease Ulcerative colitis digestive system diseases 030104 developmental biology Enzyme chemistry Biochemistry 030220 oncology & carcinogenesis biology.protein Colitis Ulcerative Female
Zdroj:	Journal of enzyme inhibition and medicinal chemistry. 31(6)
ISSN:	1475-6374
Popis:	Increases in the risk of infections and malignancy due to immune suppressive therapies of inflammatory bowel diseases (IBDs) have led the researchers to focus on more nontoxic and acceptable natural products like curcumin. Here we investigate whether prophylactic and therapeutic application of the curcumin alters the enzyme activities of paraoxonase (PON), carbonic anhydrase (CA), glucose-6-phosphate dehydrogenase (G6PD) and cytosolic beta-glucosidase in dextran sulphate sodium (DSS)-induced ulcerative colitis mice. Prophylactic application of curcumin resulted in higher MPO activity, less body weight loss and longer colon lengths compared to therapeutic group indicating preventive role of curcumin in IBDs. DSS-induced decrease in liver and serum PON activities were completely recovered by prophylactic administration of curcumin. DSS-induced reduction in liver cytosolic beta-glucosidase activity was not affected by curcumin neither in the prophylactic group nor in the therapeutic group. Erythrocyte CA activity was significantly increased in curcumin groups, however no remarkable change in G6PD activity was observed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581f50549353e2842755b9a43e33ccb9 https://pubmed.ncbi.nlm.nih.gov/27000932 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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