Early Endosomal Retention of Murine Cytomegalovirus m06 Protein
| Autor: | Natalia Kučić, Pero Lučin, Maja Ilić Tomaš, Gordana Blagojević, Hana Mahmutefendić |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
0106 biological sciences
0303 health sciences Endosome viruses 010604 marine biology & hydrobiology Congenital cytomegalovirus infection virus diseases General Chemistry Biology medicine.disease 01 natural sciences Virology 03 medical and health sciences stomatognathic system medicine murine cytomegalovirus m06/gp48 major histocompatibility class I molecules early endosomal retention 030304 developmental biology |
| Zdroj: | Croatica Chemica Acta Volume 85 Issue 2 |
| ISSN: | 1334-417X 0011-1643 |
| DOI: | 10.5562/cca1816 |
| Popis: | Murine cytomegalovirus (MCMV) encodes several genes which products interact with MHC class I molecules (MHC-I) in the secretory pathway to evade antigen presentation. The product of MCMV-m06 gene associates with nascent MHC-I proteins and redirects them into lysosomes for degradation. This report will demonstrate that MCMV-m06 protein is retained in perinuclear early endosomes together with internalized MHC-I molecules. Since we were not able to capture the MCMV-m06 protein on the cell surface, our data suggests that the MCMV-m06 protein is transported from the Golgi into early endosomal intermediates prior to their maturation into multivesicular endosomes and lysosomes. In NIH 3T3 cells with the transfected m06 gene, the endosomal localization of the m06 protein was not observed, suggesting that another MCMV function remodels the route of m06 trafficking from the Golgi towards late endosomes. (doi: 10.5562/cca1816) |
| Databáze: | OpenAIRE |
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