Circulating Haptoglobin Is an Independent Prognostic Factor in the Sera of Patients with Epithelial Ovarian Cancer
| Autor: | Huoming Zhang, Mahesh Choolani, Stephen C. L. Koh, Loganath Annamalai, Changqing Zhao, Arijit Biswas, Narasimhan Kothandaraman, Changfa Guo |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
epithelial ovarian cancer Cancer Research medicine.medical_specialty Prognostic factor Brief Article Enzyme-Linked Immunosorbent Assay Sensitivity and Specificity lcsh:RC254-282 Gastroenterology Elevated serum Internal medicine medicine Humans Epithelial ovarian cancer Tumor type In patient Neoplasms Glandular and Epithelial prognostic biomarker Aged Neoplasm Staging Proportional Hazards Models Ovarian Neoplasms CRP levels Haptoglobins biology Proportional hazards model business.industry C-reactive protein Haptoglobin Middle Aged Prognosis sandwich ELISA method lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens C-Reactive Protein Endocrinology biology.protein Female business |
| Zdroj: | Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 1, Pp 1-7 (2007) |
| ISSN: | 1476-5586 |
| Popis: | OBJECTIVE: This study was conducted to evaluate the prognostic significance of haptoglobin levels in the overall survival of patients presenting with various stages of epithelial ovarian cancer. MATERIALS AND METHODS: We employed an in-house sandwich enzyme-linked immunosorbent assay method to determine the concentrations of preoperative haptoglobin and C-reactive protein (CRP) in sera samples obtained from 66 malignant tumors, 60 benign tumors, and 10 normal healthy women. RESULTS: Levels of serum haptoglobin significantly correlated with tumor type (P < .001) and International Federation of Gynecology and Obstetrics stage (P < .05). A significant correlation was observed between clinical stage and patient survival (r = 5.99, P = .026). Our data also indicated that elevated serum haptoglobin levels were associated with poor outcome for overall survival using both univariate and multivariate analyses (P = .048 and P = .036 respectively). Using Pearson's correlation, we have noted that serum CRP concentrations significantly correlated with haptoglobin levels (r2 = 0.22, P < .001). Immunohistochemical findings and Western blot analyses were compatible with sera levels of haptoglobin in which a higher intensity of staining occurred in late-stage epithelial ovarian cancers. CONCLUSION: This study provides evidence that preoperative serum levels of haptoglobin could serve as an independent prognostic factor in patients presenting with epithelial ovarian cancer. |
| Databáze: | OpenAIRE |
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