Relationship Between Regional Brain Volumes and Cognitive Performance in the Healthy Aging: An MRI Study Using Voxel-Based Morphometry
| Autor: | Homero Vallada, Paula Squarzoni, Fabio Luiz de Souza Duran, Tania Correa Toledo de Ferraz Alves, Paulo Rossi Menezes, Marcia Scazufca, L. C. Santos, Jaqueline H. Tamashiro-Duran, Geraldo Busatto Filho |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Aging medicine.medical_specialty Statistics as Topic Population Neuropsychological Tests Audiology Developmental psychology Apolipoproteins E Cognition medicine Humans Dementia Verbal fluency test Effects of sleep deprivation on cognitive performance education Aged Analysis of Variance Brain Mapping education.field_of_study business.industry General Neuroscience Brain General Medicine Voxel-based morphometry medicine.disease Magnetic Resonance Imaging Cognitive test Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Female Orbitofrontal cortex Geriatrics and Gerontology business Parahippocampal gyrus |
| Zdroj: | Journal of Alzheimer's Disease. 31:45-58 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-2012-111124 |
| Popis: | The presence of cognitive impairment is a frequent complaint among elderly individuals in the general population. This study aimed to investigate the relationship between aging-related regional gray matter (rGM) volume changes and cognitive performance in healthy elderly adults. Morphometric magnetic resonance imaging (MRI) measures were acquired in a community-based sample of 170 cognitively-preserved subjects (66 to 75 years). This sample was drawn from the "Sao Paulo Ageing and Health" study, an epidemiological study aimed at investigating the prevalence and risk factors for Alzheimer's disease in a low income region of the city of Sao Paulo. All subjects underwent cognitive testing using a cross-culturally battery validated by the Research Group on Dementia 10/66 as well as the SKT (applied on the day of MRI scanning). Blood genotyping was performed to determine the frequency of the three apolipoprotein E allele variants (APOE e2/e3/e4) in the sample. Voxelwise linear correlation analyses between rGM volumes and cognitive test scores were performed using voxel-based morphometry, including chronological age as covariate. There were significant direct correlations between worse overall cognitive performance and rGM reductions in the right orbitofrontal cortex and parahippocampal gyrus, and also between verbal fluency scores and bilateral parahippocampal gyral volume (p < 0.05, familywise-error corrected for multiple comparisons using small volume correction). When analyses were repeated adding the presence of the APOE e4 allele as confounding covariate or excluding a minority of APOE e2 carriers, all findings retained significance. These results indicate that rGM volumes are relevant biomarkers of cognitive deficits in healthy aging individuals, most notably involving temporolimbic regions and the orbitofrontal cortex. |
| Databáze: | OpenAIRE |
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