Two for One: B-Cell Lymphomas with Features of Marginal and Follicular Lymphomas
| Autor: | Alexey Glazyrin, Lara Kujtan, Sheshadri Madhusudhana, Chirag Patel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Lymphoma B-Cell Biopsy Follicular lymphoma Biology Translocation Genetic Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Bone Marrow immune system diseases hemic and lymphatic diseases medicine Humans Lymphoma Follicular In Situ Hybridization Fluorescence B cell CD20 medicine.diagnostic_test CD23 Lymphoma B-Cell Marginal Zone Hematology General Medicine Middle Aged Marginal zone BCL6 medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Female Lymph Nodes Bone marrow Symptom Assessment Biomarkers |
| Zdroj: | Acta Haematologica. 139:84-88 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000486360 |
| Popis: | Low-grade follicular lymphomas are genetically characterized by the translocation t(14; 18)(q32;q21) with BCL2 gene rearrangements. Marginal zone lymphomas are often associated with translocations or transcriptional deregulations of the MALT gene. We report 2 cases of lymphomas which harbor both the t(14;18)(q32;q21) translocation and MALT gene upregulation. Patients presented with numerous circulating atypical lymphocytes. Lymph node biopsy in both cases on HE staining demonstrated vague nodularity readily highlighted by CD10, CD23, or BCL6. Staining with CD20 and BCL2 demonstrated monotonous diffuse effacement of normal architecture with tumor cells without obvious follicular structures. Morphologically, tumor cells were consistent with centrocytes. Bone marrow biopsy demonstrated a combined peritrabecular and interstitial distribution of the tumor cells. These cases present substantial difficulties for diagnosis and classification. Clinical and morphological features were mostly consistent with follicular lymphoma, with a few features more often seen in marginal zone lymphomas (leukemic presentation, no CD10 in circulating cells, interstitial location of tumor cells in bone marrow); therefore, these cases were finally classified as follicular lymphoma grade I. Both patients were treated with standard chemotherapy regimens for follicular and nongastric MALT lymphomas with a good response to date. |
| Databáze: | OpenAIRE |
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