Design of new protein drug delivery system (PDDS) with photoactive compounds as a potential application in the treatment of glioblastoma brain cancer
| Autor: | Maryanne Trafani de Melo, Antonio Claudio Tedesco, Henrique Luis Piva |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
Materials science Indoles medicine.medical_treatment media_common.quotation_subject Bioengineering 02 engineering and technology Drug resistance 010402 general chemistry 01 natural sciences Biomaterials Glioma Cell Line Tumor medicine Organometallic Compounds Distribution (pharmacology) Humans media_common Drug Carriers Photosensitizing Agents Brain Neoplasms 021001 nanoscience & nanotechnology medicine.disease PROTEÍNAS 0104 chemical sciences Whey Proteins Targeted drug delivery Mechanics of Materials Blood-Brain Barrier Drug delivery Cancer research Nanoparticles Nanocarriers 0210 nano-technology Glioblastoma Adjuvant |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-0191 |
| Popis: | Glioblastoma multiforme (GBM) is an extremely aggressive malignant brain tumor. Despite advances in treatment modalities, it remains largely incurable. This unfavorable prognosis for GBM is at least partly due to the lack of a successful drug delivery system across the blood-brain barrier (BBB). The delivery of drugs through nanomedicines combined with less invasive alternative therapies represents an important hope for the future of these incurable brain tumors. Whey protein nanocarriers represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug's bioavailability and distribution, and reducing the body's response towards drug resistance. They have been extensively studied to find new alternatives for capacity to encapsulate different drugs and no need for cross-linkers. In this study, we report for the first time the incorporation and administration of Aluminum phthalocyanine chloride (AlClPc)-loaded whey protein drug delivery system (AlClPc-PDDS) for the treatment of glioblastoma brain cancer. This system was designed and optimized (with the use of the spray drying technique) to obtain the required particle size (in the range of 100 to 300 nm), zeta potential and drug loading. Our results suggest that we have developed a drug delivery system from a low-cost raw material and preparation method that is capable of incorporating hydrophobic drugs which, in combination with irradiation, cause photodamage to neoplasic cells, working as an effective adjuvant treatment for malignant glioma. |
| Databáze: | OpenAIRE |
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